Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors

The major barrier for using small interfering RNA (siRNA) as cancer therapeutics is the inadequate delivery and transfection in solid tumors. We have previously shown that paclitaxel tumor priming, by inducing apoptosis, expands the tumor interstitial space, improves the penetration and dispersion o...

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Bibliographic Details
Published in:J Control Release
Main Authors: Wang, Jie, Lu, Ze, Wang, Junfeng, Cui, Minjian, Yeung, Bertrand Z., Cole, David J., Wientjes, M. Guillaume, Au, Jessie L.-S.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582943/
https://ncbi.nlm.nih.gov/pubmed/26272765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.08.012
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