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Paclitaxel Tumor-Priming Enhances siRNA Delivery and Transfection in 3-Dimensional Tumor Cultures

The clinical development of siRNA cancer therapeutics is limited by the poor interstitial transport and inefficient transfection in solid tumors. We have shown that paclitaxel pretreatment, by inducing apoptosis, causes expansion of the interstitial space and thereby improves nanoparticle delivery a...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Wong, Ho Lun, Shen, Zancong, Lu, Ze, Wientjes, M. Guillaume, Au, Jessie L.-S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109178/
https://ncbi.nlm.nih.gov/pubmed/21417439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp1004383
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