Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA-4 on mature T cells challenging. To elucidate the function of CTLA-4 on mature T cells, we have conditionally ablated Ct...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Paterson, Alison M., Lovitch, Scott B., Sage, Peter T., Juneja, Vikram R., Lee, Youjin, Trombley, Justin D., Arancibia-Cárcamo, Carolina V., Sobel, Raymond A., Rudensky, Alexander Y., Kuchroo, Vijay K., Freeman, Gordon J., Sharpe, Arlene H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577848/
https://ncbi.nlm.nih.gov/pubmed/26371185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141030
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