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Taming Tissue-specific T cells: CTLA-4 keeps self-reactive T cells at bay
CTLA-4 is a potent co-inhibitory molecule that is critical for peripheral T cell tolerance. A report in this issue reveals the autoantigen-specific nature of CTLA-4-deficient CD4(+) T cells within target tissue. In vivo studies demonstrate that CTLA-4 expression by self-reactive effector cells is su...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742103/ https://ncbi.nlm.nih.gov/pubmed/20084066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni0210-109 |
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