Blockade of CTLA-4 on CD4(+)CD25(+) regulatory T cells abrogates their function in vivo

Naturally occurring CD4(+) T(R) cells that express CD25 and the transcription factor FoxP3 play a key role in immune homeostasis preventing immune pathological responses to self and foreign antigens. CTLA-4 is expressed by a high percentage of these cells, and is often considered as a marker for T(R...

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Publicado no:J Immunol
Main Authors: Read, Simon, Greenwald, Rebecca, Izcue, Ana, Robinson, Nicholas, Mandelbrot, Didier, Francisco, Loise, Sharpe, Arlene, Powrie, Fiona
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108417/
https://ncbi.nlm.nih.gov/pubmed/16982872
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