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Blockade of CTLA-4 on CD4(+)CD25(+) regulatory T cells abrogates their function in vivo
Naturally occurring CD4(+) T(R) cells that express CD25 and the transcription factor FoxP3 play a key role in immune homeostasis preventing immune pathological responses to self and foreign antigens. CTLA-4 is expressed by a high percentage of these cells, and is often considered as a marker for T(R...
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| Pubblicato in: | J Immunol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6108417/ https://ncbi.nlm.nih.gov/pubmed/16982872 |
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