Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity

Although strategies that block FOXP3-dependent regulatory T cell function (CTLA4 blockade) and the inhibitory receptor PD1 have shown great promise in promoting antitumor immune responses in humans, their widespread implementation for cancer immunotherapy has been hampered by significant off-target...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Nawaf, Maher G., Ulvmar, Maria H., Withers, David R., McConnell, Fiona M., Gaspal, Fabrina M., Webb, Gwilym J., Jones, Nick D., Yagita, Hideo, Allison, James P., Lane, Peter J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Immunotherapy and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523579/
https://ncbi.nlm.nih.gov/pubmed/28646041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700088
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