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Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA-4 on mature T cells challenging. To elucidate the function of CTLA-4 on mature T cells, we have conditionally ablated Ct...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577848/ https://ncbi.nlm.nih.gov/pubmed/26371185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141030 |
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