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Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is essential for immunological (self-) tolerance, but due to the early fatality of CTLA-4 KO mice, its specific function in central and peripheral tolerance and in different systemic diseases remains to be determined. Here, we further examined the role of CT...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Klocke, Katrin, Sakaguchi, Shimon, Holmdahl, Rikard, Wing, Kajsa
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855592/
https://ncbi.nlm.nih.gov/pubmed/27071130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603892113
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