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Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
Thymus-produced CD4(+) regulatory T (Treg) cells, which specifically express the transcription factor forkhead box p3, are potently immunosuppressive and characteristically possess a self-reactive T-cell receptor (TCR) repertoire. To determine the molecular basis of Treg suppressive activity and the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677445/ https://ncbi.nlm.nih.gov/pubmed/23690575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307185110 |
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