CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is of pivotal importance for self-tolerance, with deficiency or unfavorable polymorphisms leading to autoimmune disease. Tolerance to self-antigens is achieved through thymic deletion of highly autoreactive conventional T (Tconv) cells and...

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Main Authors: Verhagen, Johan, Genolet, Raphaël, Britton, Graham J., Stevenson, Brian J., Sabatos-Peyton, Catherine A., Dyson, Julian, Luescher, Immanuel F., Wraith, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549118/
https://ncbi.nlm.nih.gov/pubmed/23267099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208573110
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