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CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is of pivotal importance for self-tolerance, with deficiency or unfavorable polymorphisms leading to autoimmune disease. Tolerance to self-antigens is achieved through thymic deletion of highly autoreactive conventional T (Tconv) cells and...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549118/ https://ncbi.nlm.nih.gov/pubmed/23267099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208573110 |
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