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Highly diverse TCRα chain repertoire of pre-immune CD8(+) T cells reveals new insights in gene recombination

Although the T-cell receptor αδ (TCRαδ) locus harbours large libraries of variable (TRAV) and junctional (TRAJ) gene segments, according to previous studies the TCRα chain repertoire is of limited diversity due to restrictions imposed by sequential coordinate TRAV-TRAJ recombinations. By sequencing...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Genolet, Raphael, Stevenson, Brian J, Farinelli, Laurent, Østerås, Magne, Luescher, Immanuel F
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321212/
https://ncbi.nlm.nih.gov/pubmed/22373576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.48
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