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Highly diverse TCRα chain repertoire of pre-immune CD8(+) T cells reveals new insights in gene recombination
Although the T-cell receptor αδ (TCRαδ) locus harbours large libraries of variable (TRAV) and junctional (TRAJ) gene segments, according to previous studies the TCRα chain repertoire is of limited diversity due to restrictions imposed by sequential coordinate TRAV-TRAJ recombinations. By sequencing...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321212/ https://ncbi.nlm.nih.gov/pubmed/22373576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.48 |
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