Chargement en cours...
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
Foxp3-expressing CD4(+)CD25(+) regulatory T cells (Tregs) constitutively and highly express the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), whose Treg-specific deficiency causes severe systemic autoimmunity. As a key mechanism of Treg-mediated suppression, Treg-e...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2021
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325248/ https://ncbi.nlm.nih.gov/pubmed/34301886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023739118 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|