Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

Foxp3-expressing CD4(+)CD25(+) regulatory T cells (Tregs) constitutively and highly express the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), whose Treg-specific deficiency causes severe systemic autoimmunity. As a key mechanism of Treg-mediated suppression, Treg-e...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Tekguc, Murat, Wing, James Badger, Osaki, Motonao, Long, Jia, Sakaguchi, Shimon
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325248/
https://ncbi.nlm.nih.gov/pubmed/34301886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023739118
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki