Загрузка...
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
Foxp3-expressing CD4(+)CD25(+) regulatory T cells (Tregs) constitutively and highly express the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), whose Treg-specific deficiency causes severe systemic autoimmunity. As a key mechanism of Treg-mediated suppression, Treg-e...
Сохранить в:
| Опубликовано в: : | Proc Natl Acad Sci U S A |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2021
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325248/ https://ncbi.nlm.nih.gov/pubmed/34301886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023739118 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|