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Overexpression of the CTLA-4 isoform lacking exons 2 and 3 causes autoimmunity()
CTLA-4 is a potent inhibitor of T cell activation, primarily upon binding to its costimulatory ligands (B7.1 and B7.2) expressed on antigen presenting cells. However, variants of CTLA-4 can also function independently of B7 molecules. 1/4CTLA-4 is a highly conserved isoform encoded by exons 1 and 4...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245861/ https://ncbi.nlm.nih.gov/pubmed/22124121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102042 |
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