Overexpression of the CTLA-4 isoform lacking exons 2 and 3 causes autoimmunity()

CTLA-4 is a potent inhibitor of T cell activation, primarily upon binding to its costimulatory ligands (B7.1 and B7.2) expressed on antigen presenting cells. However, variants of CTLA-4 can also function independently of B7 molecules. 1/4CTLA-4 is a highly conserved isoform encoded by exons 1 and 4...

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Main Authors: Liu, Sue M, Sutherland, Andrew P R, Zhang, Zheng, Rainbow, Daniel B, Quintana, Francisco J, Paterson, Alison M., Sharpe, Arlene H., Oukka, Mohamed, Wicker, Linda S, Kuchroo, Vijay K
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245861/
https://ncbi.nlm.nih.gov/pubmed/22124121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102042
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