Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in Nonobese Diabetic mice

Idd5.1 regulates T1D susceptibility in NOD mice and has two notable candidate genes, Ctla4 and Icos. Reduced expression of one of the four CTLA-4 isoforms, ligand independent CTLA-4 (liCTLA-4), which inhibits in vitro T cell activation and cytokine production similarly to full length CTLA-4 (flCTLA-...

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Detalhes bibliográficos
Main Authors: Araki, Manabu, Chung, Denise, Liu, Sue, Rainbow, Daniel B., Chamberlain, Giselle, Garner, Valerie, Hunter, Kara M. D., Vijayakrishnan, Lalitha, Peterson, Laurence B., Oukka, Mohamed, Sharpe, Arlene H., Sobel, Raymond, Kuchroo, Vijay K., Wicker, Linda S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871291/
https://ncbi.nlm.nih.gov/pubmed/19783679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802610
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