Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

Mutations in parkin lead to early-onset autosomal recessive Parkinson’s disease (PD) and inactivation of parkin is thought to contribute to sporadic PD. Adult knockout of parkin in the ventral midbrain of mice leads to an age-dependent loss of dopamine neurons that is dependent on the accumulation o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Stevens, Daniel A., Lee, Yunjong, Kang, Ho Chul, Lee, Byoung Dae, Lee, Yun-Il, Bower, Aaron, Jiang, Haisong, Kang, Sung-Ung, Andrabi, Shaida A., Dawson, Valina L., Shin, Joo-Ho, Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577198/
https://ncbi.nlm.nih.gov/pubmed/26324925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500624112
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