PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson’s Disease

A hallmark of Parkinson’s disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here we identify a new Parkin Interacting Substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parki...

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Autors principals: Shin, Joo-Ho, Ko, Han Seok, Kang, Hochul, Lee, Yunjong, Lee, Yun-Il, Pletinkova, Olga, Troconso, Juan C., Dawson, Valina L., Dawson, Ted M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063894/
https://ncbi.nlm.nih.gov/pubmed/21376232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.02.010
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