Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

Mutations in parkin lead to early-onset autosomal recessive Parkinson’s disease (PD) and inactivation of parkin is thought to contribute to sporadic PD. Adult knockout of parkin in the ventral midbrain of mice leads to an age-dependent loss of dopamine neurons that is dependent on the accumulation o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Stevens, Daniel A., Lee, Yunjong, Kang, Ho Chul, Lee, Byoung Dae, Lee, Yun-Il, Bower, Aaron, Jiang, Haisong, Kang, Sung-Ung, Andrabi, Shaida A., Dawson, Valina L., Shin, Joo-Ho, Dawson, Ted M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577198/
https://ncbi.nlm.nih.gov/pubmed/26324925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500624112
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