Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs

BH3 profiling measures the propensity of transformed cells to undergo intrinsic apoptosis and is determined by exposing cells to BH3-mimicking peptides. We hypothesized that basal levels of prosurvival BCL-2 family proteins may modulate the predictive power of BH3 profiling and termed it mitochondri...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ishizawa, Jo, Kojima, Kensuke, McQueen, Teresa, Ruvolo, Vivian, Chachad, Dhruv, Nogueras-Gonzalez, Graciela M., Huang, Xuelin, Pierceall, William E., Dettman, E. J., Cardone, Michael H., Shacham, Sharon, Konopleva, Marina, Andreeff, Michael
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573975/
https://ncbi.nlm.nih.gov/pubmed/26375587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138377
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