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Pharmacological activation of wild-type p53 in the therapy of leukemia
The tumor suppressor p53 is inactivated by mutations in a majority of human solid tumors. Conversely, in leukemias p53 mutations are rare since they are only observed in a small fraction of the patient population, predominately in patients with complex karyotype acute myeloid leukemia or hypodiploid...
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| Publié dans: | Exp Hematol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5062953/ https://ncbi.nlm.nih.gov/pubmed/27327543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.05.014 |
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