Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial

Targeted therapies against FLT3-mutated acute myeloid leukemias have shown limited clinical efficacy primarily because of the acquisition of secondary mutations in FLT3 and persistent activation of downstream pro-survival pathways such as MEK/ERK, PI3K/AKT, and STAT5. Activation of these additional...

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Pubblicato in:Haematologica
Autori principali: Zhang, Weiguo, Ly, Charlie, Ishizawa, Jo, Mu, Hong, Ruvolo, Vivian, Shacham, Sharon, Daver, Naval, Andreeff, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165819/
https://ncbi.nlm.nih.gov/pubmed/29773601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.185082
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