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Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation

Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood. It is known, however, that cytokines activate neutral sphingomyelinase (nSMase) and nSMase has downstream effects with the potential to increase calp...

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書目詳細資料
發表在:Am J Physiol Lung Cell Mol Physiol
Main Authors: Supinski, Gerald S., Alimov, Alexander P., Wang, Lin, Song, Xiao-Hong, Callahan, Leigh A.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572417/
https://ncbi.nlm.nih.gov/pubmed/26138644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00141.2015
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