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Muscle-specific calpastatin overexpression prevents diaphragm weakness in cecal ligation puncture-induced sepsis

Recent work indicates that infections are a major contributor to diaphragm weakness in patients who are critically ill and mechanically ventilated, and that diaphragm weakness is a risk factor for death and prolonged mechanical ventilation. Infections activate muscle calpain, but many believe this i...

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Detalhes bibliográficos
Main Authors: Supinski, Gerald S., Wang, Lin, Song, Xiao-Hong, Moylan, Jennifer S., Callahan, Leigh Ann
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199992/
https://ncbi.nlm.nih.gov/pubmed/25170071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00975.2013
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