Muscle-specific calpastatin overexpression prevents diaphragm weakness in cecal ligation puncture-induced sepsis

Recent work indicates that infections are a major contributor to diaphragm weakness in patients who are critically ill and mechanically ventilated, and that diaphragm weakness is a risk factor for death and prolonged mechanical ventilation. Infections activate muscle calpain, but many believe this i...

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Bibliographic Details
Main Authors: Supinski, Gerald S., Wang, Lin, Song, Xiao-Hong, Moylan, Jennifer S., Callahan, Leigh Ann
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199992/
https://ncbi.nlm.nih.gov/pubmed/25170071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00975.2013
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