Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-β1-induced kidney injury in a mouse model of diabetes

AIMS/HYPOTHESIS: We investigated whether heterogeneous nuclear ribonucleoprotein F (hnRNP F) stimulates renal ACE-2 expression and prevents TGF-β1 signalling, TGF-β1 inhibition of Ace-2 gene expression and induction of tubulo-fibrosis in an Akita mouse model of type 1 diabetes. METHODS: Adult male A...

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Publicado no:Diabetologia
Main Authors: Lo, Chao-Sheng, Shi, Yixuan, Chang, Shiao-Ying, Abdo, Shaaban, Chenier, Isabelle, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572079/
https://ncbi.nlm.nih.gov/pubmed/26232095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3700-y
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