Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney

We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 we...

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Published in:Sci Rep
Main Authors: Ghosh, Anindya, Zhao, Shuiling, Lo, Chao-Sheng, Maachi, Hasna, Chenier, Isabelle, Lateef, Muhammad Abdul, Abdo, Shaaban, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491582/
https://ncbi.nlm.nih.gov/pubmed/31040360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43218-2
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