Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice

We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia...

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Bibliographic Details
Published in:Diabetes
Main Authors: Lo, Chao-Sheng, Shi, Yixuan, Chenier, Isabelle, Ghosh, Anindya, Wu, Chin-Han, Cailhier, Jean-Francois, Ethier, Jean, Lattouf, Jean-Baptiste, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S.D.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2017
Subjects:
Complications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482081/
https://ncbi.nlm.nih.gov/pubmed/28424160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1588
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