Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice

Oxidative stress induces endogenous antioxidants via nuclear factor erythroid 2–related factor 2 (Nrf2), potentially preventing tissue injury. We investigated whether insulin affects renal Nrf2 expression in type 1 diabetes (T1D) and studied its underlying mechanism. Insulin normalized hyperglycemia...

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Vydáno v:Endocrinology
Hlavní autoři: Ghosh, Anindya, Abdo, Shaaban, Zhao, Shuiling, Wu, Chin-Han, Shi, Yixuan, Lo, Chao-Sheng, Chenier, Isabelle, Alquier, Thierry, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2017
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460794/
https://ncbi.nlm.nih.gov/pubmed/28324005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1576
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