TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET complex, but evidence for their predicted spatiote...

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Publicat a:Cell Rep
Autors principals: Kurima, Kiyoto, Ebrahim, Seham, Pan, Bifen, Sedlacek, Miloslav, Sengupta, Prabuddha, Millis, Bryan A., Cui, Runjia, Nakanishi, Hiroshi, Fujikawa, Taro, Kawashima, Yoshi, Choi, Byung Y., Monahan, Kelly, Holt, Jeffrey R., Griffith, Andrew J., Kachar, Bechara
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569002/
https://ncbi.nlm.nih.gov/pubmed/26321635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.058
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