Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia

WHRN (DFNB31) mutations cause diverse hearing disorders: profound deafness (DFNB31) or variable hearing loss in Usher syndrome type II. The known role of WHRN in stereocilia elongation does not explain these different pathophysiologies. Using spontaneous and targeted Whrn mutants, we show that the m...

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Publicado en:Cell Rep
Main Authors: Ebrahim, Seham, Ingham, Neil J., Lewis, Morag A., Rogers, Michael J.C., Cui, Runjia, Kachar, Bechara, Pass, Johanna C., Steel, Karen P.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2016
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Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859837/
https://ncbi.nlm.nih.gov/pubmed/27117407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.081
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