Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia

WHRN (DFNB31) mutations cause diverse hearing disorders: profound deafness (DFNB31) or variable hearing loss in Usher syndrome type II. The known role of WHRN in stereocilia elongation does not explain these different pathophysiologies. Using spontaneous and targeted Whrn mutants, we show that the m...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Ebrahim, Seham, Ingham, Neil J., Lewis, Morag A., Rogers, Michael J.C., Cui, Runjia, Kachar, Bechara, Pass, Johanna C., Steel, Karen P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859837/
https://ncbi.nlm.nih.gov/pubmed/27117407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.081
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