TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET complex, but evidence for their predicted spatiote...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kurima, Kiyoto, Ebrahim, Seham, Pan, Bifen, Sedlacek, Miloslav, Sengupta, Prabuddha, Millis, Bryan A., Cui, Runjia, Nakanishi, Hiroshi, Fujikawa, Taro, Kawashima, Yoshi, Choi, Byung Y., Monahan, Kelly, Holt, Jeffrey R., Griffith, Andrew J., Kachar, Bechara
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569002/
https://ncbi.nlm.nih.gov/pubmed/26321635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.058
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