TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET complex, but evidence for their predicted spatiote...

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Vydáno v:Cell Rep
Hlavní autoři: Kurima, Kiyoto, Ebrahim, Seham, Pan, Bifen, Sedlacek, Miloslav, Sengupta, Prabuddha, Millis, Bryan A., Cui, Runjia, Nakanishi, Hiroshi, Fujikawa, Taro, Kawashima, Yoshi, Choi, Byung Y., Monahan, Kelly, Holt, Jeffrey R., Griffith, Andrew J., Kachar, Bechara
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569002/
https://ncbi.nlm.nih.gov/pubmed/26321635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.058
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