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Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea
Functional mechanoelectrical transduction (MET) channels of cochlear hair cells require the presence of transmembrane channel-like protein isoforms TMC1 or TMC2. We show that TMCs are required for normal stereociliary bundle development and distinctively influence channel properties. TMC1-dependent...
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| Publicado no: | Nat Commun |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5988745/ https://ncbi.nlm.nih.gov/pubmed/29872055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04589-8 |
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