NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets

Studies in animal models and human subjects have shown that both innate and adaptive immunity contribute to the pathogenesis of type 1 diabetes (T1D). Whereas the role of TLR signaling pathways in T1D has been extensively studied, the contribution of the nucleotide-binding oligomerization domain, le...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Hu, Changyun, Ding, Heyuan, Li, Yangyang, Pearson, James A., Zhang, Xiaojun, Flavell, Richard A., Wong, F. Susan, Wen, Li
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568693/
https://ncbi.nlm.nih.gov/pubmed/26305961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513509112
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