NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets

Studies in animal models and human subjects have shown that both innate and adaptive immunity contribute to the pathogenesis of type 1 diabetes (T1D). Whereas the role of TLR signaling pathways in T1D has been extensively studied, the contribution of the nucleotide-binding oligomerization domain, le...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hu, Changyun, Ding, Heyuan, Li, Yangyang, Pearson, James A., Zhang, Xiaojun, Flavell, Richard A., Wong, F. Susan, Wen, Li
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568693/
https://ncbi.nlm.nih.gov/pubmed/26305961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513509112
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