NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets

Studies in animal models and human subjects have shown that both innate and adaptive immunity contribute to the pathogenesis of type 1 diabetes (T1D). Whereas the role of TLR signaling pathways in T1D has been extensively studied, the contribution of the nucleotide-binding oligomerization domain, le...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hu, Changyun, Ding, Heyuan, Li, Yangyang, Pearson, James A., Zhang, Xiaojun, Flavell, Richard A., Wong, F. Susan, Wen, Li
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568693/
https://ncbi.nlm.nih.gov/pubmed/26305961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513509112
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