VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function

Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal trafficking. Mutations of VPS35 have been linked to familial Parkinson’s disease (PD). Here we showed that specific deletion of the VPS35 gene in DA neurons resulted in PD-like deficits including loss of DA neurons and accumul...

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Vydáno v:Cell Rep
Hlavní autoři: Tang, Fu-Lei, Liu, Wei, Hu, Jin-Xia, Erion, Joanna Ruth, Ye, Jian, Mei, Lin, Xiong, Wen-Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565770/
https://ncbi.nlm.nih.gov/pubmed/26321632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.001
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