Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex

BACKGROUND: Vacuolar sorting protein 35 (VPS35), a critical component of retromer, is essential for selective endosome-to-Golgi retrieval of membrane proteins. It is highly expressed in microglial cells, in addition to neurons. We have previously demonstrated microglial VPS35’s functions in preventi...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Ye, Shi-Yang, Apple, Joanna E., Ren, Xiao, Tang, Fu-Lei, Yao, Ling-Ling, Wang, Yong-Gang, Mei, Lin, Zhou, Yuan-Guo, Xiong, Wen-Cheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880612/
https://ncbi.nlm.nih.gov/pubmed/31771656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1633-y
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