Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice

Vacuolar sorting protein 35 (VPS35) is a critical component of retromer, which is essential for selective endosome-to-Golgi retrieval of membrane proteins. VPS35 deficiency is implicated in neurodegenerative disease pathology, including Alzheimer's disease (AD). However, exactly how VPS35 loss...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Appel, Joanna Ruth, Ye, Shiyang, Tang, Fulei, Sun, Dong, Zhang, Hongsheng, Mei, Lin, Xiong, Wen-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021995/
https://ncbi.nlm.nih.gov/pubmed/29853629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3621-17.2018
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