Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis

Adult hippocampal neurogenesis is believed to maintain a range of cognitive functions, many of which decline with age. We recently reported that radial neural stem cells (rNSCs) in the hippocampus undergo activation-dependent conversion into astrocytes, a mechanism that over time contributes to a re...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Sierra, Amanda, Martín-Suárez, Soraya, Valcárcel-Martín, Roberto, Pascual-Brazo, Jesús, Aelvoet, Sarah-Ann, Abiega, Oihane, Deudero, Juan J., Brewster, Amy L., Bernales, Irantzu, Anderson, Anne E., Baekelandt, Veerle, Maletić-Savatić, Mirjana, Encinas, Juan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443499/
https://ncbi.nlm.nih.gov/pubmed/25957904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.04.003
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