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VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function
Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal trafficking. Mutations of VPS35 have been linked to familial Parkinson’s disease (PD). Here we showed that specific deletion of the VPS35 gene in DA neurons resulted in PD-like deficits including loss of DA neurons and accumul...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4565770/ https://ncbi.nlm.nih.gov/pubmed/26321632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.001 |
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