Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis

VPS35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson’s disease (PD) and Alzheimer’s disease (AD), both neuro-degeneration disord...

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Sonraí Bibleagrafaíochta
Main Authors: Liu, Wei, Tang, Fu-Lei, Erion, Joanna, Xiao, Hang, Ye, Jian, Xiong, Wen-Cheng
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016418/
https://ncbi.nlm.nih.gov/pubmed/24512632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-7-10
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