VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

VPS35, a major component of the retromer complex, is important for endosome-to-Golgi retrieval of membrane proteins. Although implicated in Alzheimer’s disease (AD), how VPS35 regulates AD-associated pathology is unknown. In this paper, we show that hemizygous deletion of Vps35 in the Tg2576 mouse m...

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Detalhes bibliográficos
Main Authors: Wen, Lei, Tang, Fu-Lei, Hong, Yan, Luo, Shi-Wen, Wang, Chun-Lei, He, Wanxia, Shen, Chengyong, Jung, Ji-Ung, Xiong, Fei, Lee, Dae-hoon, Zhang, Quan-Guang, Brann, Darrell, Kim, Tae-Wan, Yan, Riqiang, Mei, Lin, Xiong, Wen-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257571/
https://ncbi.nlm.nih.gov/pubmed/22105352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201105109
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