VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1

VPS35, a major component of the retromer, plays an important role in the selective endosome-to-Golgi retrieval of membrane proteins. Dysfunction of retromer is a risk factor for neurodegenerative disorders, but its function in developing mouse brain remains poorly understood. Here we provide evidenc...

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Bibliographic Details
Main Authors: Wang, Chun-Lei, Tang, Fu-Lei, Peng, Yun, Shen, Cheng-Yong, Mei, Lin, Xiong, Wen-Cheng
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522886/
https://ncbi.nlm.nih.gov/pubmed/23259059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20122451
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