VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation

BACKGROUND: Vacuolar protein sorting 35 (VPS35), a key component of retromer, plays an important role in endosome-to-Golgi retrieval of membrane proteins. Dysfunction of VPS35/retromer is a risk factor for neurodegenerative disorders, including AD (Alzheimer’s disease) and PD (Parkinson’s disease)....

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Publicado en:Mol Brain
Autores principales: Tian, Yun, Tang, Fu-Lei, Sun, XiangDong, Wen, Lei, Mei, Lin, Tang, Bei-Sha, Xiong, Wen-Cheng
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628247/
https://ncbi.nlm.nih.gov/pubmed/26521016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-015-0156-4
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