Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells

PURPOSE: Vacuolar protein sorting 35 (Vps35) mutations and protein dysfunction have been linked to the hyperphosphorylation and accumulation of tau protein in a number of central neurodegenerative disorders. The aims of the present study were to investigate the mechanism underlying the tau hyperphos...

Full description

Saved in:
Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Gao, Ling, Xiao, Hang, Ai, Li-Qian-Yu, Chen, Chunlin, Lin, Sen, Zhou, Yuanguo, Ye, Jian, Liu, Wei
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2020
Subjects:
Biochemistry and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205187/
https://ncbi.nlm.nih.gov/pubmed/31995153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.1.1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items