p47(phox) deficiency improves cognitive impairment and attenuates tau hyperphosphorylation in mouse models of AD

BACKGROUND: Alzheimer’s disease (AD) is characterized by progressive memory loss and cognitive impairment. The aggregation of amyloid β (Aβ) and hyperphosphorylated tau protein are two major pathological features of AD. Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) has bee...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Gong, Ping, Chen, Yan-qing, Lin, Ai-hua, Zhang, Hai-bo, Zhang, Yan, Ye, Richard D., Yu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659091/
https://ncbi.nlm.nih.gov/pubmed/33183342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00714-2
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