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Molecular pharmacodynamics of emixustat in protection against retinal degeneration
Emixustat is a visual cycle modulator that has entered clinical trials as a treatment for age-related macular degeneration (AMD). This molecule has been proposed to inhibit the visual cycle isomerase RPE65, thereby slowing regeneration of 11-cis-retinal and reducing production of retinaldehyde conde...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4563688/ https://ncbi.nlm.nih.gov/pubmed/26075817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80950 |
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