Molecular pharmacodynamics of emixustat in protection against retinal degeneration

Emixustat is a visual cycle modulator that has entered clinical trials as a treatment for age-related macular degeneration (AMD). This molecule has been proposed to inhibit the visual cycle isomerase RPE65, thereby slowing regeneration of 11-cis-retinal and reducing production of retinaldehyde conde...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Zhang, Jianye, Kiser, Philip D., Badiee, Mohsen, Palczewska, Grazyna, Dong, Zhiqian, Golczak, Marcin, Tochtrop, Gregory P., Palczewski, Krzysztof
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563688/
https://ncbi.nlm.nih.gov/pubmed/26075817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80950
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