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Catalytic mechanism of a retinoid isomerase essential for vertebrate vision
Visual function in vertebrates is dependent on the membrane-bound retinoid isomerase, RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for rod and cone opsins. The mechanism by which RPE65 catalyzes stereoselective retinoid isomerization has remained elusiv...
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| Publié dans: | Nat Chem Biol |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4433804/ https://ncbi.nlm.nih.gov/pubmed/25894083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1799 |
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