Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

Visual function in vertebrates is dependent on the membrane-bound retinoid isomerase, RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for rod and cone opsins. The mechanism by which RPE65 catalyzes stereoselective retinoid isomerization has remained elusiv...

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Published in:Nat Chem Biol
Main Authors: Kiser, Philip D., Zhang, Jianye, Badiee, Mohsen, Li, Qingjiang, Shi, Wuxian, Sui, Xuewu, Golczak, Marcin, Tochtrop, Gregory P., Palczewski, Krzysztof
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433804/
https://ncbi.nlm.nih.gov/pubmed/25894083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1799
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